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August 20, 2026

Joint Health 3.0: What to Take When Glucosamine Didn’t Work

You know the twenty minutes. You get out of bed and your knees need most of a cup of coffee before they feel like yours again. You stand up after a lo

August 20, 2026

Native Type II Collagen: The Joint Ingredient That Works Through Your Immune System

You notice it going downstairs. That’s usually where it shows up first, in the specific moment a knee has to bend under load and would rather not. T

Joint Health 3.0: What to Take When Glucosamine Didn’t Work

You know the twenty minutes. You get out of bed and your knees need most of a cup of coffee before they feel like yours again. You stand up after a long stretch of sitting and there’s a pause, a small negotiation, before you commit to it. Somewhere along the way, you started saying no to things. The Sunday pickup basketball game. The garden project. The trip with a lot of walking on it. Life got smaller and your activities shrinked. I’m 52, I ski 80+ days a season, mountain bike, paddleboard, surf, and play pickleball. Lately that has meant working through a knee problem. So I did what I did for 15 years as a functional medicine clinician working with thousands of patients, and what I’ve...

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Native Type II Collagen: The Joint Ingredient That Works Through Your Immune System

You notice it going downstairs. That’s usually where it shows up first, in the specific moment a knee has to bend under load and would rather not. Then it’s squatting down to reach something on a bottom shelf, and getting back up. If you’ve been at this a while, you’ve probably already tried the obvious things. Glucosamine and chondroitin, because that’s what everyone recommends. Maybe a collagen powder in your morning coffee. Some people get real relief from those. Plenty don’t. Native type II collagen is different because it doesn’t belong to the same family of ideas. Every joint supplement you’ve taken asked you for grams. This one asks for 40 milligrams, about the weight of two grains of rice. That difference is neither a marketing trick...

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Eggshell Membrane: Fast-Acting Joint Support Hiding in Your Breakfast

There’s a bottle in your cupboard you stopped taking. Possibly two. You bought it for your knees, took it faithfully for a few weeks, felt nothing you could point to, and at some point stopped remembering. That’s the joint supplement experience for most people, and it isn’t a story about willpower. Most of these ingredients need eight to twelve weeks before they’ll show you anything. You’re being asked to keep faith with a capsule through two months of no feedback, which is a lot to ask of anyone whose knees hurt right now. Eggshell membrane is the exception in that aisle. In controlled research, the difference showed up in about ten days. Why it moves that fast comes down to what it is and how it works. What...

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Boswellia: The Inflammation Pathway Your Painkiller Doesn’t Touch

You take more ibuprofen than you’d like to. Most people with aching knees do, and most of them carry the same low-grade unease about it. Maybe your doctor has mentioned your stomach, or your blood pressure. Or maybe you’ve read enough on your own to be wary of taking something daily for the next twenty years. Those drugs work well on one kind of inflammation, and they were never built to touch the other kind. Your body has two separate assembly lines for inflammatory signals, and the entire category of common anti-inflammatories works on one line while the other runs at full speed. Boswellia works on the line they miss. That’s why it adds something rather than duplicating what you’re already doing, and it’s why an independent...

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RHR: My Top 3 Ingredients for Joint Health, Mobility, and Cartilage Repair

In this episode we discuss: Why immune function plays a surprising role in osteoarthritis How native type II collagen, NEM, and Boswellia serrata compare to glucosamine and chondroitin The research-backed dosages used in clinical trials Safety considerations and who should consult a healthcare provider Lifestyle habits that maximize joint recovery and resilience Show notes: “Efficacy of eggshell membrane in knee osteoarthritis: A systematic review and meta-analysis” by García-Muñoz, A. M., et al. “2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee” by Kolasinski, S. L., et al. “Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: A multicenter randomized, double-blind, placebo-controlled study” by Lugo, J. P., et al. “Beneficial effects of natural eggshell membrane versus placebo in exercise-induced joint pain,...

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RHR: Why Microglia Are the Key to Brain Health, with Dr. David Perlmutter

In this episode we discuss: What microglia are and why they’re essential for maintaining healthy brain function How chronic inflammation can transform protective microglia into drivers of neurodegeneration The emerging science of immunometabolism and mitochondrial function Why insulin resistance, obesity, and type 2 diabetes dramatically increase dementia risk The limitations of the traditional amyloid hypothesis and what newer research suggests How lifestyle interventions have demonstrated measurable improvements in cognitive outcomes The powerful connection between the gut microbiome, systemic inflammation, and brain health Why sleep, exercise, and nutrition remain the most impactful tools for protecting the brain The truth about the APOE4 gene—and why genetics are not destiny Show notes: [embedded content] There’s been a lot of discussion about brain health over the past several years, and particularly in the context of dementia and cognitive decline....

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RHR: Your Mouth is Talking To Your Brain—And You Should Be Listening

In this episode we discuss: The connection between periodontal disease and cognitive decline How oral bacteria may access and influence the brain The emerging evidence linking periodontal disease and Alzheimer’s disease The role of Porphyromonas gingivalis and gingipains in neurodegeneration The newly identified oral-gut-brain pathway and microbiome disruption What current research suggests about oral health and Parkinson’s disease The gap between medical and dental care when addressing systemic disease Practical prevention strategies to support oral and cognitive health Show notes: “Oral frailty and neurodegeneration in Alzheimer’s disease” by Dibello, V., et al. “Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors” by Dominy, S.S., et al. “Oral health’s inextricable connection to systemic health: Special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions” by...

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RHR: Fibermaxxing: Why the Internet’s Hottest Gut Health Trend Gets It Half Right

In this episode we discuss: What the “fibermaxxing” trend gets right—and wrong Why whole-food fiber and isolated fiber supplements are not equivalent The importance of short-chain fatty acids like butyrate for gut health Why microbiome diversity influences fiber tolerance Common symptoms caused by excessive fermentable fiber intake Differences between soluble and insoluble fiber Surprising research linking high fiber intake with diverticulosis prevalence Safer supplemental options for sensitive guts Show notes: “Short chain fatty acids in human gut and metabolic health” by Blaak, E. E., et al “Intestinal fatty acid-binding protein and gut permeability responses to exercise” by March, D. S., et al “A high-fiber diet does not protect against asymptomatic diverticulosis” by Peery, A. F., et al “Diet and supplements and their impact on colorectal cancer” by Pericleous, M., Mandair, D., & Caplin, M. E. “Carbohydrate quality and human...

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RHR: Revisiting the Gut-Immune Axis

In this episode we discuss: The role of the microbiome in immune regulation Intestinal permeability (“leaky gut”) and its systemic effects Lipopolysaccharides and chronic inflammation The link between gut dysfunction and chronic diseases “Inflammaging” and the gut’s role in aging How modern life disrupts gut health Practical strategies to support the gut-immune axis Show notes: “Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review” by Di Vincenzo, F., et al. “Oral supplementation with bovine colostrum decreases intestinal permeability and stool concentrations of zonulin in athletes” by Haląsa, M., et al. “Lactoferrin reduces the risk of respiratory tract infections: a meta-analysis of randomized controlled trials” by Ali, A. S., et al. “Akkermansia muciniphila and gut immune system: a good friendship that attenuates inflammatory bowel disease, obesity, and diabetes” by Rodrigues, V. F., et al. “Aging and inflammation” by...

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RHR: Beyond the Headlines: A Functional Medicine Approach to Microplastics

In this episode we discuss: Where microplastics accumulate in the body and why size matters How exposure happens: food, water, air, and household environments Links between microplastics and cardiovascular risk, inflammation, and dementia Effects on the gut microbiome and systemic health The “Trojan horse” effect: chemical additives like BPA, phthalates, and PFAS Ways to reduce exposure in daily life– food storage, cookware, and household materials The role of diet, sleep, exercise, and detox pathways Targeted support: antioxidants, NAC, sulforaphane, fiber, and binders A functional medicine framework for resilience in a toxic environment Show notes: “Microplastics: A real global threat for environment and food safety: A state of the art review” by Ziani, K., et al. “Microplastics and nanoplastics in atheromas and cardiovascular events” by Marfella, R., et al. “Bioaccumulation of microplastics in decedent human brains” by Nihart, A.J.,...

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