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RHR: Beyond the Headlines: A Functional Medicine Approach to Microplastics

May 5, 2026
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In this episode we discuss: Where microplastics accumulate in the body and why size matters How exposure happens: food, water, air, and household environments Links between microplastics and cardiovascular risk, inflammation, and dementia Effects on the gut microbiome and systemic health The “Trojan horse” effect: chemical additives like BPA, phthalates, and PFAS Ways to reduce exposure in daily life– food storage, cookware, and household materials The role of diet, sleep, exercise, and detox pathways Targeted support: antioxidants, NAC, sulforaphane, fiber, and binders A functional medicine framework for resilience in a toxic environment Show notes: “Microplastics: A real global threat for environment and food safety: A state of the art review” by Ziani, K., et al. “Microplastics and nanoplastics in atheromas and cardiovascular events” by Marfella, R., et al. “Bioaccumulation of microplastics in decedent human brains” by Nihart, A.J.,...

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RHR: The Sleep Optimization Trap: Are You Tracking Yourself Into Worse Sleep?

April 28, 2026
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In this episode we discuss: What sleep trackers get right—and where they go wrong The rise of orthosomnia and why it’s becoming more common How sleep anxiety triggers cortisol and disrupts rest The “hyperarousal” model of insomnia explained Why perfectionist beliefs about sleep can backfire When sleep tracking is useful—and when it becomes harmful Why CBT-I is the gold standard for insomnia treatment The importance of managing daytime stress for better sleep A new framework: sleep as a biological process, not a performance metric Show notes: “Orthosomnia: Are some patients taking the quantified self too far?” by Baron, K.G., et al “HPA axis activity in patients with chronic insomnia: A systematic review and meta-analysis of case–control studies” by Dressle, R.J., et al. “Dysfunctional beliefs and attitudes about sleep (DBAS) mediate outcomes in dCBT-I on psychological distress, fatigue, and...

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RHR: The GLP-1 Blind Spot: What Ozempic Won’t Do for Your Metabolic Health

April 21, 2026
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In this episode we discuss: How GLP-1 drugs work  Proven benefits, common side effects, and discontinuation rates Emerging long-term risks of GLP-1 use The risk of nutrient deficiencies from reduced food intake Muscle loss & body composition changes Weight regain after discontinuing use The lack of root-cause treatments addressing diet, lifestyle, and metabolic drivers Who benefits most from GLP-1s vs. who may not Using GLP-1s as part of a broader health strategy Show notes: “Discontinuing glucagon-like peptide-1 receptor agonists and body habitus: A systematic review and meta-analysis” by Berg, S., et al “Trajectory of weight regain after cessation of GLP-1 receptor agonists: A systematic review and nonlinear meta-regression” by Budini, B., et al “Nutritional deficiencies and muscle loss in adults with type 2 diabetes using GLP-1 receptor agonists: A retrospective observational study” by Butsch, W.S., et al “Taking back...

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RHR: Shaking Up the Salt Myth

April 14, 2026
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In this episode we discuss: How the anti-salt movement began Major studies that challenge the narrative Why sodium is essential Potential downsides of sodium restriction Who should actually reduce sodium The overlooked role of potassium Tips for choosing a salt and practical takeaways Show notes: “Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies” by Mente, A., et al. “Urinary sodium and potassium excretion and risk of cardiovascular events” by O’Donnell, M. J., et al. “Fatal and nonfatal outcomes, incidence of hypertension, and blood pressure changes in relation to urinary sodium excretion” by Stolarz-Skrzypek, K., et al. “Shaking Up The Salt Myth” series by Kresser, C. Learn more about the Adapt Naturals Core Plus bundle, or take our quiz to see which products best suit...

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RHR: Mouth Taping: Beyond the Hype—What the Science Really Says

April 7, 2026
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In this episode we discuss: Why nasal breathing is the body’s preferred breathing pathway How mouth breathing affects sleep quality, oral health, and airway resistance The latest systematic review on mouth taping and what it found Potential risks of mouth taping, including worsened sleep apnea and suffocation risk with nasal obstruction The phenomenon of “mouth puffing” and how it may worsen sleep apnea Why airway anatomy determines whether mouth taping helps or harms Why mouth taping may work better when combined with other interventions The importance of diagnosing sleep disorders before trying sleep hacks Safer ways to approach mouth taping if you decide to try it Show notes: “Nocturnal mouth-taping and social media: A scoping review of the evidence” by Fangmeyer, S. K., Badger, C. D., & Thakkar, P. G. “Effect of nasal or oral breathing route...

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RHR: Erythritol: The ‘Safe’ Sweetener That’s Anything But

March 31, 2026
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In this episode we discuss: Why erythritol became the go-to sweetener for “sugar-free” and keto products New evidence linking erythritol to increased risk of heart attack and stroke The FDA’s GRAS designation and how it failed to catch long-term risks Gut health effects of sugar alcohols, including IBS-like symptoms Safer alternatives to erythritol, including allulose, pure stevia, and monk fruit When small amounts of real sugar may be less harmful than chronic sweetener use Practical label-reading tips to avoid hidden erythritol and guidance for sweetener use Show notes: [embedded content] Hey everybody, Chris Kresser here. Welcome to another episode of Revolution Health Radio. If you’re trying to lose weight, manage your blood sugar, or follow a keto diet, chances are you’ve reached for products labeled “sugar-free” or “zero calorie.” Maybe it’s a protein...

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RHR: Preserving Cognitive Function As You Age, with Tommy Wood

March 24, 2026
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In this episode we discuss: The history of Alzheimer’s disease and what it reveals about modern dementia research Why most late-onset dementia is heterogeneous and largely preventable The Lancet Commission findings on modifiable dementia risk factors Dr. Wood’s 3S Model of Brain Health Why retirement often accelerates cognitive decline—and how to redesign later life for brain health The difference between “brain training” and truly brain-stimulating activities How complex, coordinated physical activities outperform simple exercise for cognitive resilience Key nutrients for long-term cognitive health, including B vitamins, omega-3s, vitamin D, iron, and polyphenols What really matters most for sleep when it comes to protecting the brain Show notes: The Stimulated Mind by Dr. Tommy Wood Better Brain Fitness podcast Better Brain Fitness Substack Better Brain personalized brain check-ups and expert coaching “Dementia prevention, intervention, and care: 2024 report of the Lancet...

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RHR: New Study Challenges the Plant-Based Longevity Myth

March 17, 2026
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In this episode we discuss: Overview of a 20-year longevity study Why vegetarians and vegans had lower odds of reaching 100 The risks of nutrient deficiencies in elderly populations Protein needs, sarcopenia, and muscle preservation with age Key nutrients difficult to obtain from plants alone Why one-size-fits-all nutrition advice fails Practical guidance for omnivores, vegetarians, and vegans Show notes: [embedded content] Hey everybody, Chris Kresser here. Welcome to another episode of Revolution Health Radio. Today I’m discussing a study just published in the American Journal of Clinical Nutrition. It challenges one of the most persistent narratives in nutrition, that plant-based diets are the key to longevity and we should all eliminate or drastically reduce animal foods to live longer, healthier lives. If you’ve been listening to this podcast, you know I’m not anti-plants. Far...

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RHR: Beyond the Gut: The Microbiome’s Role in Sleep, Energy, and Longevity, with Dr. Zain Kassam

March 10, 2026
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In this episode we discuss: The role of microbial diversity in sleep quality and overall resilience Emerging research linking the microbiome to eye health, sinus health, skin conditions, and autoimmune disease How modern life—diet, stress, medications, and environmental exposures—disrupts microbial balance The “4D framework” for evaluating probiotics Why melatonin dosing matters (and why more isn’t better) The emerging category of cobiotics– supplements designed to support both the host and the microbiome simultaneously The future of microbiome-directed healthcare and personalized interventions Show notes: Use code CHRIS20 for 20% off your first order at Seed.com Follow Seed on Instagram If you’d like to ask a question for Chris to answer in a future episode, submit it here Follow Chris on Instagram or Facebook [embedded content] Hey everybody, Chris Kresser here. Welcome to another episode of Revolution Health Radio. This week...

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RHR: The Gut-Brain Connection: How Your Microbiome Affects Your Mental Health

February 24, 2026
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In this episode we discuss: Why the “chemical imbalance” theory of depression falls short The immune–cytokine model of depression How gut inflammation and intestinal permeability affect the brain The role of butyrate in reducing inflammation and increasing BDNF New research on probiotics and mental health outcomes Why probiotic strain specificity matters Bacillus coagulans and its dual gut–brain benefits Diet, supplementation, and functional testing strategies How gut-focused care can complement—not replace—conventional treatment Show notes: “So depression is an inflammatory disease, but where does the inflammation come from?” by Berk, M., et al. “Anxiolytic- and antidepressant-like effects of Bacillus coagulans Unique IS-2 mediate via reshaping of microbiome gut-brain axis in rats” by Satti, S., et al. “Immune dysregulation in depression and anxiety: A review of the immune response in disease and treatment” by Hole, C., et al. “From gut to glee:...

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